TRIANGLE OF HEALTH

Triangle of Health: Overview

The Kyäni Triangle of Health is a powerful, easy to use wellness system that provides unmatched nutrition for optimal health. It consists of three key products that are taken throughout the day, working together to bring you key nutrients.

Kyäni Sunrise combines polyphenol-rich Wild Alaskan Blueberries with other natural extracts for a delicious, vitamin-packed powerhouse to help you get your day started right.

Kyäni Sunset is an excellent source of essential omega-3 fatty acids from fish including Wild Alaskan Salmon and other naturally sourced ingredients, as well as Tocotrienols, to support healthy systems throughout the body.

The true key to realizing the full value of the Triangle of Health is Kyäni Nitro. Nitro contains extracts from the noni fruit, which your body can use to produce Nitric Oxide—one of the most important signaling molecules in the body. Nitric Oxide, which promotes healthy circulations and helps ensure your body’s ability to absorb nutrients. Available as Nitro FX and Nitro Xtreme, Nitro is taken two to three times per day for maximum effectiveness and maximum nutrient absorption.

Click here to view our "Brilliance from Bush to Bottle" document

Scientific Board

Certifications

Kyäni’s Scientific Advisory Board consists of prestigious doctors and scientists who have dedicated their lives to achieving health and wellness, advances in medicine and science, and helping people around the world Experience More! Kyäni’s Scientific Advisory Board plays an active role in perfecting Kyäni’s existing products and helping develop new products. Additionally, they share their knowledge and expertise with Kyäni’s distributors. Kyäni’s doctors teach distributors how and why Kyäni’s products have such a dramatic effect on health and wellness. Kyäni’s Scientific Advisory Board also compiles the strong scientific research that has been conducted on the ingredients in Kyäni’s products, making research just a click away.

Dr. Clair Francomano, MD

Dr. Clair Francomano, MD

Dr. Thomas Burke, PHD

Dr. Thomas Burke, PHD

Dr. Andreas Boettcher

Dr. Andreas Boettcher

Patricia Morrone

Patricia Morrone

Dr. Clair Francomano, MD

Dr. Clair Francomano is a graduate of Yale College and Johns Hopkins University School of Medicine. She trained in Internal Medicine at Johns Hopkins and spent 11 years as a full-time faculty member there. In 1994, she left Johns Hopkins to become the first Clinical Director for the National Human Genome Research Institute at the National Institute of Health.

In 2005, Dr. Francomano became the Director of Adult Genetics at the Greater Baltimore Medical Center where she sees genetics patients at the Harvey Institute for Human Genetics. She also works with the Internal Medicine residents to bring genetics to the care of adult patients. Dr. Francomano is recognized internationally for her contributions to the field of hereditary disorders of connective tissue. She has authored more than 110 articles in peer-reviewed literature and 33 book chapters and reviews.

In addition to her expertise in genetics and the hereditary disorders of connective tissue, Dr. Francomano has a long interest in integrative medicine, including nutritional supplementation and applications of energy medicine to optimize health. Kyäni is proud to have Dr. Francomano on the Kyäni Scientific Advisory Board.

Daily Use for Healthy Living
Sunrise + Nitro

Sunrise + Nitro

1 ml Nitro & 1 oz. Sunrise

AM
Sunrise + Nitro

Nitro or Nitro Xtreme

1 ml

ANYTIME
Sunrise + Nitro

Sunset + Nitro

1 ml Nitro & 3 Sunset softgels

PM

Kyäni Sunrise

Kyäni Sunrise was developed to harness the powerful antioxidant polyphenols in the wild Alaskan Blueberry. But that is just the beginning. Sunrise includes extracts from 22 superfoods and a wide variety of vitamins and minerals to optimize wellness.

With its water-soluble nutrients, Kyäni Sunrise is taken in the morning to maximize bioavailability. Available in a bottle or single-serve pouches, Sunrise is a delicious and healthy way to start the day.

BENEFITS OF TAKING KYÄNI SUNRISE

  • Enables effective stress management
  • Maintains heart health
  • Supports the immune system
  • Encourages Health digestion
  • Promotes joint flexibility
  • Helps maintain energy
  • Supports cognitive function
  • Promotes positive mental health

Complete Nutritional Spectrum

Nutritional Spectrum
Nutritional Spectrum
Nutritional Spectrum

Nature has created a variety of adaptations that help protect plants from the harsh stresses of the environment. These protective pigments, called anthocyanins, are one of the key antioxidant ingredients in Kyäni Sunrise. Featuring superfoods including the Wild Alaskan Blueberry along with a host of other powerful natural ingredients in a delicious blend, Kyäni Sunrise is the perfect way to start your day.


Kyäni Sunrise contains many health-promoting vitamins and trace minerals including:

Vitamin B1 (Thiamine)

  • Supports a healthy circulatory system
  • Promotes a healthy nervous system
  • Converts proteins, carbohydrates, and fats into energy
  • Kyäni Sunrise contains 3 mg of Vitamin B1 per 1 oz. serving

VITAMIN B2 (RIBOFLAVIN)

  • Provides energy to cells in the body
  • Maintains normal hormone levels
  • Encourages the production of healthy blood cells
  • Promotes neurotransmitter function
  • Maintains healthy eyes and skin
  • Kyäni Sunrise contains 3.4 mg of Vitamin B2 per 1 oz. serving

VITAMIN B3 (NIACIN)

  • Essential for a healthy nervous system
  • Maintains proper digestive function
  • Helps hormone production
  • Helps convert proteins, carbohydrates, and fats into energy
  • Encourages the production of healthy blood cells
  • Kyäni Sunrise contains 40 mg of Vitamin B3 per 1 oz. serving

VITAMIN B5 (PANTOTHENIC ACID)

  • Supports normal growth and development
  • Supports the body's stress coping mechanism.
  • Helps convert proteins, carbohydrates, and fats into energy
  • Supports proper wound healing
  • Plays a role in the production of bile, vitamin D, red blood cells, adrenal gland hormones, and neurotransmitters
  • Kyäni Sunrise contains 20 mg of Vitamin B5 per 1 oz. serving

VITAMIN B6 (PYRIDOXINE)

  • Supports a healthy heart and circulation
  • Promotes proper nerve function
  • Encourages a healthy immune system
  • Maintains healthy muscle function
  • Helps convert proteins, carbohydrates, and fats into energy
  • Plays a role in the production of hormones, red blood cells, enzymes, brain function, and skin health
  • Kyäni Sunrise contains 4 mg of Vitamin B6 per 1 oz. serving

VITAMIN B12 (CYANOCOBLAMIN)

  • Essential to the production of red blood cells
  • Assists in the creation of DNA material
  • Supports a healthy nervous system
  • Helps convert proteins, carbohydrates, and fats into energy
  • Kyäni Sunrise contains 200 mcg of Vitamin B12 per 1 oz. serving

VITAMIN C (ASCORBIC ACID)

  • Prevents free radical damage
  • Vital for a healthy immune system
  • Essential to the production of collagen (necessary for tissue repair)
  • Promotes healthy gums, skin, and vision
  • Helps synthesize hormones
  • Kyäni Sunrise contains 60 mg of Vitamin C per 1 oz. serving

VITAMIN B9 (FOLIC ACID)

  • Helps in the production of genetic material (DNA and RNA)
  • Vital to healthy cell division and replication
  • Promotes proper fetal development
  • Encourages a healthy gastrointestinal tract
  • Supports the immune system
  • Maintains healthy gums, red blood cells, and skin
  • Kyäni Sunrise contains 400 mcg of Vitamin B9 per 1 oz. serving

D-BIOTIN

  • Promotes energy metabolism
  • Maintains healthy hair, skin, and nails
  • Essential for the growth and development of children
  • Helps convert proteins, carbohydrates, and fats into energy
  • Kyäni Sunrise contains 600 mcg of Biotin per 1 oz. serving

TAURINE

  • Promotes a healthy heart
  • Supports proper vision
  • Helps maintain proper blood pressure and cholesterol levels
  • Promotes the body's natural detoxification process
  • Encourages the body's response to fatigue and lactic acid
  • Decreases lactic acid to reduce fatigue
  • Kyäni Sunrise contains 1,000 mg of Taurine per 1 oz. serving

L-THEANINE

  • Promotes relaxation response to decrease stress
  • Enhances alpha waves in the brain
  • Serves as a powerful antioxidant
  • Maintains healthy immune function
  • Supports proper blood flow
  • Kyäni Sunrise contains 50 mg of L-Theanine per 1 oz. serving

INOSITOL

  • Essential for DNA production
  • Supports nerve transmission
  • Vital to the growth and reproduction of cells
  • Helps natural metabolization of fat
  • Kyäni Sunrise contains 25 mg of Inositol per 1 oz. serving
  • Kyäni Sunrise also contains a variety of trace minerals that support proper functions throughout the body

 

Science

Studies on Blueberries:

Researchers have found that blueberries contain many health-promoting properties including high levels of antioxidants. A study conducted by the US Department of Agriculture determined that blueberries have the highest total antioxidant capacity per serving when compared to 24 varieties of fresh fruits, 23 vegetables, 16 herbs and spices, 10 different nuts, and 4 dried fruits.

Due to the harsh growing conditions of Alaska, Wild Alaskan Blueberries have even higher nutritional values than common blueberries. In fact, studies have shown that Wild Alaskan Blueberries have at least ten times higher antioxidant levels than the common blueberry.

“When it comes to brain protection, there is nothing quite like blueberries. Call the blueberry the brain berry.”
-Dr. James Joseph, Ph D,
Lead scientist in the Laboratory of Neuroscience at the USDA Nutrition Research Center On Aging at Tufts University.

 

ADDITIONAL STUDIES ON BLUEBERRIES:

Agricultural Research Magazine. U.S. Department of Agriculture: Agricultural Research Service. Nutrition and Brain Function: Food for the Aging Mind. Aug. 2007. ars.usda.gov

Andres-Lacueva C, Shukitt-Hale B, Galli RL, et al. Anthocyanins I aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci. 2005 Apr;8(2):111-20.

Faria A, Oliveira J, Neves P, et al. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts. J Agric Food Chem. 2005 Aug 24;53(17):6896-902.

Journal of Agricultural and Food Chemistry, 2004 Jun 16;52(12):4026-37

Journal of Agricultural and Food Chemistry, 2005 May 4;53(9):3403-7 Journal of Agricultural and Food Chemistry, 52:4026-4037, 2004 Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. BR J Nutr. 2002 Oct;88(4):389-98.

Lau, et al., “The beneficial effects of fruit polyphenols on brain aging.” Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. Neurobiology of Aging. 26S (2005) S128–S132. ddr.nal.usda.gov

Underwood A. So berry good for you; rediscovering the health benefits of berries. Newsweek. June 17, 2002.

Daniells, Stephen. Blueberry powder may slow breast tumor growth: Mouse data. Nutra ingredients-usa.com. Sept 20, 2011.

 

Read the White PaperView Product Label

Kyäni Sunset

Kyäni Sunset was designed to contain only lipid-soluble elements, maximizing the bio-availability of these nutrients for absorption. Sunset is a proprietary combination of tocotrienols (the most potent form of vitamin E), Omega-3s derived from Wild Alaskan Sockeye Salmon (the purest source in the world), Beta Carotene (a natural source of Vitamin A), and the essential Vitamin D. The health benefits of tocotrienols, Omega-3, Beta Carotene, and Vitamin D are well documented by medical professionals and researchers. Kyäni Sunset offers unparalleled nutritional support to the body’s vital systems including cell health and support for the cardiovascular and immune systems. Comprised of only lipid-soluble nutrients, Sunset is intended for evening use when the body’s lipid activities are at their peak. Sunset gives the body what it needs when it needs it. Because of this, Kyäni Sunset is the perfect nutritional complement to water-soluble nutrients offered by Kyäni Sunrise™.

9 BENEFITS OF TAKING KYÄNI SUNSET *

  • Supports Cardiovascular Health
  • Supports Healthy Inflammatory Response
  • Encourages Healthy Skin and Hair
  • Helps Maintain Healthy Cholesterol Levels
  • Helps Maintain Healthy Blood Sugar Levels
  • Supports Cognitive Function
  • Supports Cell Membranes
  • Very Potent Vitamin E
  • Promotes Healthy Immune Response

* In healthy individuals. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Powerful Nutrients that supportHeart & Immune System Response

Kyäni Sunset contains many health-promoting vitamins and trace minerals including:

VITAMIN E

Recently discovered tocotrienol Vitamin E has exhibited substantial benefits to the cardiovascular system including helping to maintain healthy blood pressure. Tocotrienols have also proven to be very effective supporters of cell health including protection from oxidation.

In the past, the majority of scientific research focused on the less-effective form of Vitamin E called alpha-tocopherols, while as little as one percent focused on the potent tocotrienol Vitamin E. However a significant shift has taken place over the last few years as a much larger portion of peer-reviewed research articles have been centered on tocotrienols. It's becoming more clear that, at the molecular level, tocotrienols are a much more potent and effective source of Vitamin E.

TOCOTRIENOLS

The annatto bush, an oily plant that grows in South America, is the only natural compound in the world that offers pure Tocotrienols without the accompanying Tocopherols that may limit the benefits. Furthermore, annatto Tocotrienol has the highest Tocotrienol concentrations with 150 – 300 times fewer Tocopherols than rice and palm sources. Only Kyäni Sunset™ contains annatto Tocotrienols, offering the most health benefits.

OMEGA-3S

Omega-3s are an essential fatty acid required for optimal health. This healthy molecule is found in every cell of the body, particularly in the brain and heart. Because the body doesn't produce these oils on its own, they must be obtained through dietary consumption.

Delivered from Wild Alaskan Sockeye Salmon and other wild fish, Kyäni Sunset™ contains extremely high levels of both EPA and DHA forms of Omega-3s. Studies show that Omega-3s strongly support the body's healthy inflammation response, maintaining proper vascularization throughout the body and supporting artery and heart health.

VITAMIN A (BETA-CAROTENE)

Beta-carotene is an organic compound found abundantly in plants and vegetables. A member of the carotenoids, it can be metabolized into Vitamin A, yielding many compelling health benefits. These include heart health, cell protection, and heightened immunity. This essential nutrient is also beneficial in sustaining optical health and brain function.

Beta-carotene is lipid-soluble and acts as an antioxidant, protecting cells from oxidation damage. With the addition of this powerful compound in Sunset, you’ll be giving your body more of what it needs.

VITAMIN D3

Vitamin D is one of several vitamins required for normal growth and development. This essential nutrient contributes to the absorption of calcium, which is an important process for bone development and strength. Vitamin D promotes cellular growth, boosts the immune system, and helps support proper inflammatory response. Studies have also shown that Vitamin D assists in maintaining healthy blood pressure and sustaining cardiovascular health. One unique aspect of Vitamin D is that it can be created by our bodies with the aid of sun exposure. However, studies show an alarming rate of Vitamin D deficiency in the USA. Since most Americans are not producing enough on their own, Vitamin D supplementation can provide the support and protection the body needs from this essential nutrient.

video

 

Science

TOCOTRIENOLS

Tocotrienols (bixa orellana) are part of the Vitamin E family. Tocotrienols were originally discovered by Pennock and Whittle in 1964. In the early 1980s, Tocotrienols were shown to help maintain healthy cholesterol. Since then, Tocotrienols have been studied extensively in numerous clinical trials and are proven effective in supporting proper blood cholesterol levels in healthy individuals.

TOCOPHEROLS AND TOCOTRIENOLS: THE VITAMIN E FAMILY

Tocopherol (T)
5. Alpha-T
6. Beta-T
7. Gamma-T
8. Delta-T

Tocotrienols (T3)
1. Alpha-T3
2. Beta-T3
3. Gamma-T3
4. Delta-T3

STUDIES ON TOCOTRIENOLS

Tocotrienol - Wikipedia

Graveline, Duane. Tocotrienols in Combat: Fighting the Statin Damage Crisis. Whole Foods Magazine. Oct. 2011.

Whole Foods Magazine

TOCOTRIENOLS AND HEART HEALTH

Pearce BC, Parker RA, Deason ME, Qureshi AA, Wright JJ (October 1992). "Hypocholesterolemic activity of synthetic and natural tocotrienols". J. Med. Chem. 35 (20): 3595–606. doi:10.1021/jm00098a002. PMID 1433170.

^ Tan DT, Khor HT, Low WH, Ali A, Gapor A (April 1991). "Effect of a palm-oil-vitamin E concentrate on the serum and lipoprotein lipids in humans". The American Journal of Clinical Nutrition 53 (4 Suppl): 1027S–1030S. PMID 2012011.

Pearce, B.C., et al., Hypocholesterolemic activity of synthetic and natural tocotrienols. Med Chem, 1992. 35(20): p. 3595-606.

Kooyenga, D.K., et al., Antioxidants modulate the course of carotid atherosclerosis: A four-year report., in Micronutrients and Health, K. Nesaretnam and L. Packer, Editors. 2001, AOCS Press: Illinois. p. 366-375.

Tan, B. and A.M. Mueller, Tocotrienols in Cardiometabolic Diseases., Tocotrienols: Vitamin E beyond Tocopherol, R. Watson and V. Preedy, Editors. 2008, AOCS/CRC Press. p. 257-273. Naito, Y., et al., Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules. Atherosclerosis, 2005. 180(1): p. 19-25.

ASTAZANTHIN

Fassett, R.G. and J.S. Coombes, Astaxanthin, oxidative stress, inflammation and cardiovascular disease. Future Cardiol, 2009. 5(4): p. 333-42. Tocotrienols and Cancer Cells

Shibata, A., et al., delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not. J Agric Food Chem, 2009. 57(18): p. 8696-704.

Miyazawa, T., et al., Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). J Nutr Biochem, 2009. 20(2): p. 79-86.

TOCOTRIENOLS AND RADIATION

Kulkarni, S., S. P. Ghosh, et al. "Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation." Radiat Res 173(6): 738-47.

Ghosh, S. P., S. Kulkarni, et al. (2009). "Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector." Int J Radiat Biol 85(7): 598-606.

Satyamitra, M. M., S. Kulkarni, et al. "Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform delta-Tocotrienol." Radiat Res 175(6): 736-45.

Li, X. H., D. Fu, et al. "Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling." Haematologica 95(12): 1996-2004.


View the Product LabelView the White Paper

Kyäni Nitro

Kyäni Nitro is the key that unlocks the full power of the Triangle of Health. One of the most important signaling molecules in the body is Nitric Oxide, which promotes healthy circulation and helps ensure your body’s ability to absorb nutrients.

Our Nitro products contain extracts from the noni fruit, which your body can use to produce Nitric Oxide. Available as Nitro FX and Nitro Xtreme, Nitro is taken two to three times per day for maximum effectiveness and maximum nutrient absorption.

9 BENEFITS OF TAKING KYÄNI NITRO

  • Promotes Energy
  • Encourages Blood Flow
  • Promotes Circulation
  • Enables Healthy Inflammation Response
  • Encourages Heart Health
  • Supports Healthy Sexual Function
  • Supports Cognitive Function
  • Sustains the Immune System
  • Supports Nutrient Absorption

Kyäni Nitro Family

KYÄNI NITRO FX

KYÄNI NITRO FX

Kyäni NitroFX is a proprietary blend of noni concentrate that increases the body's natural production of Nitric Oxide (NO). Also known as the Molecule of Life, Nitric Oxide repairs, defends, and maintains every cell of the body. Studied extensively by researchers and physicians, Nitric Oxide has been touted as a powerful, health-promoting molecule by a large number of scientific papers.

KYÄNI NITRO XTREME

KYÄNI NITRO XTREME

Built upon the foundation of Kyäni Nitro FX, Kyäni Nitro Xtreme contains even more nitrate from the proprietary blend of Noni concentrate for increased Nitric Oxide (NO) production in the body. In addition, Nitro Xtreme™ contains CoQ10, Magnesium, Zinc, Chromium, and Niacin. Among many other benefits, these additional nutrients also boost the body's production of Nitric Oxide. Kyäni Nitro Xtreme™ is specifically designed for the most demanding parts of your day. Whether you're an athlete, business professional, student, or busy parent, Nitro Xtreme is perfect for supporting energy, physical stamina, and mental clarity.

THE NITRO EFFECT

KYÄNI NITRO BENEFITS

Nitric Oxide: The Molecule of Life

In 1998, three scientists were awarded the Nobel Prize in Physiology of Medicine for their work on Nitric Oxide. Now called “The Molecule of Life,” Nitric Oxide has been shown to positively influence:

Blood Circulation

One of Nitric Oxide's most important qualities is the ability to dilate the blood vessels, thus maintaining healthy circulation and heart health.

Inflammation

Nitric Oxide is a “signaling molecule” that supports healthy inflammatory response.

Brain Function

Nitric Oxide is an essential chemical messenger, supporting the body's natural ability to store and retrieve information in the brain.

Digestion

Nitric Oxide supports motility and microcirculation, promoting blood flow and nutrient delivery throughout the body.

Sexual Function

Nitric Oxide has been shown to maintain healthy blood flow, which is essential to proper sexual libido, performance, and satisfaction.

“In my 25 years of research, I have never seen a molecule [like Nitric Oxide] that so pervasively influences normal and abnormal body functions.”
-Dr. Solomon Snyder Director of Neuroscience, John Hopkins Medical School


KYÄNI NITRO INGREDIENTS

Both Nitro FX™ and Nitro Xtreme™ contain Kyäni’s proprietary blend of Noni concentrate for increased Nitric Oxide production. Kyäni Nitro Xtreme™ contains additional components to give your body an extra boost. Research shows that the combination of these five ingredients enhances the production of Nitric Oxide in the body and maximizes the body's potential to utilize it.

COQ10

Coenzyme Q10 (CoQ10) is an antioxidant produced by the human body. It is required for the basic functioning of cells. CoQ10 helps generate up to 95 percent of the human body's energy. This molecule also promotes cardiovascular health and proper blood flow. CoQ10 levels are reported to decrease with age and chronic diseases.

MAGNESIUM

Magnesium helps convert carbohydrates, protein, sugars, and fats into energy. It also supports muscle relaxation and contraction as well as nerve transmission. Some studies show that increased magnesium is one of the most effective ways to boost energy. The Journal of Nutrition reported that low magnesium levels take a significant toll on the body's energy supply.

ZINC

Essential to more than 300 enzymes in the body, zinc plays an important role in maintaining a healthy immune system, energy metabolism, protein synthesis, blood sugar balance, wound healing, and brain function.

CHROMIUM

Chromium helps turn carbohydrates, proteins, and fats into energy. This essential mineral also helps the body regulate blood sugar levels, maintain heart health, improve the immune system, and maintain healthy lean body mass.

NIACIN (VITAMIN B3)

Niacin is an anti-oxidant essential for cellular metabolism. It is involved in over 50 metabolic processes that turn carbohydrates and fats into energy. Niacin also helps maintain heart health, supports the digestive tract, and promotes a healthy nervous system.

More on the Recent Nitro Study

Nitro Study

Here’s a little more detail on the recent study conducted on Kyäni Nitro Xtreme. We began by selecting human aortic endothelial cells, which line the walls of the circulatory system. This is where Nitro helps produce the Nitric Oxide after you take it. We then tested the reaction of the cells to Nitro Xtreme, compared to morphine in terms of Nitric Oxide production.

Here are the results:

Nitro Study Results

In less than five minutes, both Nitro and morphine had increased Nitric Oxide production significantly. As shown above, the Nitro stimulated Nitric Oxide production to nearly the same level as morphine. The nitrates contained in Kyäni Nitro help stimulate Nitric Oxide production with a nutritionally superior alternative to drugs that can produce the same effect. The Nitro Effect makes a difference and supports the body’s ability to transport the nutrients you consume. You can see all of our Nitro products here.

Source: The Effect of Test Samples on the Modulation of the Production of Nitric Oxide by Human Aortic Endothelial Cells (HAoEC). Trinity Bioactives,2018

 

Science

NITRIC OXIDE

Nitric Oxide is a simple molecule, made up of one part nitrogen and one part oxygen. Scientists and researchers around the globe have been astonished by the seemingly limitless list of the functions of Nitric Oxide in the body. “In my 25 years of research, I have never seen a molecule that so pervasively influences normal and abnormal body functions,” said Dr. Solomon Snyder, the director of neuroscience at Johns Hopkins Medical School.

Despite the significance of this molecule, Nitric Oxide is relatively unknown outside the medical research community. Nitric Oxide is a highly reactive gas that is naturally produced in the human body. Nitric Oxide is the most important signaling molecule in the body. It supports a wide range of physiological functions including healthy circulation, proper inflammatory response, normal learning and memory, correct digestion, and correct oxygen release in tissues from red blood cells. It plays a significant role in many important chemical reactions. With today’s fast-paced lifestyle and factors like lack of exercise, poor diet, soil mineral depletion, cigarette smoke, and other air pollutants, supporting healthy levels of Nitric Oxide in humans is of critical importance.

Scientifically speaking, Nitric Oxide can be produced in the body through the process of converting L-arginine (one of the 20 amino acids) into citrulline. However, more and more research suggests that L-arginine has potentially negative side effects. Additionally, many co-factors are required to convert L-arginine into Nitric Oxide. Alternatively, Nitric Oxide can be produced more efficiently from substances know as nitrates and nitrites found in plants like Morinda Citrofolia (noni).

During 1999 and 2000, Dr. Thomas Burke and his researchers at Integrated Systems Physiology, an independent lab in Denver, Colorado, discovered that noni fruit juice was a raw material the body could use to synthesize Nitric Oxide. Their findings helped to explain the enormous benefits some people had reported after consuming noni juice.

Kyäni Nitro FX™ and Kyäni Nitro Xtreme™ were developed using a proprietary blend of noni concentrate to maximize the Nitric Oxide impact of Noni consumption. These extraordinary products utilize groundbreaking research to unlock the secret of noni.

“In my 25 years of research, I have never seen a molecule [like Nitric Oxide] that so pervasively influences normal and abnormal body functions.”
-Dr. Solomon Snyder, Director of Neuroscience, John Hopkins Medical School

ADDITIONAL BENEFITS OF NITRIC OXIDE

Nitric Oxide positively affects nearly every system in the body, promoting better health and wellness. Well-documented for its role as a natural vasodilator, Nitric Oxide dilates the blood vessels, maintaining proper cardiovascular health. But that’s just the beginning. Look at how many more ways Nitric Oxide can benefit the human body…

  • Supports healthy fat burning within cells
  • Assists the body's natural wound-healing process
  • Encourages normal lung health
  • Promotes natural resistance to viruses and bacteria
  • Maintains healthy digestive function
  • Promotes natural restful sleep
  • Helps maintain healthy blood sugar levels

Fact: If you cut off the oxygen to the heart, the heart will suffer irreversible damage or cell death in 5-7 minutes. If you terminate nitric oxide, it takes only 5 seconds.

STUDIES ON NITRIC OXIDE

McKnight, et al. “Chemical Synthesis of Nitric Oxide in the stomach from dietary nitrate in humans.”
Gut. 1997 Feb; 40 (2):211-4.

GUO, et al. “Identification of a plant Nitric Oxide synthase gene involved in hormonal signaling.”
Science, 2003 Oct 3; 302(5642):100-3.

Del Rio, L., Corpas, F. and Barrosos, J. “Nitric Oxide and Nitric Oxide synthase activity in plants.”
Phytochemistry 2004 Apr; 65(7):783-92

Schaffer, et al. “Nitric Oxide regulates wound healing.”
J Surg Res. 1996; 63: 237-240

Taubert, et al. “Aspirin induces Nitric Oxide release from vascular endothelium: a novel mechanism of action.”
British Journal of Pharmacology 2004; 143: 159-165.

Hancock, C. and Riegger-Krugh, C. “Modulation of pain in osteoarthritis: the role of nitric oxide.”
Clin J Pain. 2008 May;24(4):353-65.

Jeschonneck, et al. “Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia.”
Rheumatology (Oxford). 2000; 39:917-921.

Akerstrom, et al.,“Nitric Oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.”
Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control. J Virol. 2005 Feb;79(3):1966-9. ncbi.nlm.nih.gov

Nitric oxide: From menace to marvel of the decade
nitromd.com

Reproductive and Cardiovascular Disease Research Group
squl.ac.uk

Arthritis Research & Therapy
arthritis research

UC Irvine researchers reveal structure of molecule that regulates blood pressure
ucihealth.com

The Building Blocks of Erection: Nitric Oxide . . . and More Nitric Oxide
hopkinsmedicine.org

Spiraling high blood pressure linked to Nitric Oxide deficiency
ucihealth.com

NITRIC OXIDE PREVENTS BLOOD VESSEL INFLAMMATION
hopkinsmedicine.org

NITRIC OXIDE LINKS BULK OF SPORADIC AND FAMILIAL PARKINSON'S DISEASE
hopkinsmedicine.org

Study Points to Role of Nitric Oxide in New Treatments for Sickle Cell Anemia
nih.gov

Cortical feedback to the thalamus is selectively enhanced by nitric oxide.
ncbi.nlm.nih.gov

Nitric Oxide Deficiency Raises Cardiovascular Disease Risk in African Americans
news.research.ohiou.edu

Study: Nitric Oxide Key to Brain 'Booting Up'
foxnews.com

Heart Disease Risk Factor #1: Nitric Oxide
rd.com

Nitric Oxide Converted in the Stomach
McKnight, G.M., et al., “Chemical synthesis of Nitric Oxide in the stomach from dietary nitrate in humans.”
Gut. 1997; 40: 211-4.

Nitric Oxide and the Blood
“Duke researchers discover central role of Nitric Oxide in hemoglobin action.”
Duke Medicine News and Communication. 3 Nov. 2004. dukehealth.org

Gladwin, M., et al. “Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.”
Proc Natl Acad Sci U S A. 2000 Oct. 10; 97(21): 11482-7.

Blood flow and Alzheimer’s
Mazza, M., et al., “Primary cerebral blood flow deficiency and Alzheimer's disease: shadows and lights.”
J Alzheimers Dis. 2011 Jan 1;23(3):375-89.

Bone Health
Health News Report “Exercise and Vitamin D Help Prevent Falls in Seniors.”
2010 Dec 23. healthnewsreport.blogspot.com

Nazrun, A.S., M. Norazlina, M. Norliza and S.I. Nirwana, 2011. Tocotrienols as an anti-osteoporotic agent: The progress so far. Int. J. Osteoporosis Metab. Disorders, 1: 1-14.

Nitric oxide: novel therapy for osteoporosis.”
Expert Opin Pharmacother. 2008 Dec;9(17):3025-44.

Nitric Oxide and Recovery
Diwan, A., et al.“Nitric Oxide modulates fracture healing.”
J Bone Miner Res. 2000 Feb;15(2):342-51.

THE ABILITY OF SAMPLES TO MODULATE ANGIOGENESIS

Summary

  • The extract of Kyäni's proprietary noni blend was tested at two concentrations in the presence and the absence of Vascular Endothelial Growth Factor (VEGF) for its ability to inhibit angiogenesis using the aortic ring model.
  • The rings treated with VEGF alone exhibited growth of the microvessels over the 7 days of the investigation.
  • At no one point of time was any microvessel growth observed when the aortic rings were cultured in the presence of two different concentrations of Kyäni's proprietary noni blend extract.
  • Furthermore the two concentrations of noni blend also completely prevented any vessel growth in rings treated with VEGF.

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